Prostate cancer
The application of IORT during radical prostatectomy is feasible without significant acute rectal toxicity.
Intraoperative radiotherapy (IORT) has been used in treating patients with prostate cancer candidates for radical prostatectomy. The prostate tissue has been exposed to a total dose of 10-12 Gy produced by a dedicated linear electron accelerator with beveled collimators and the procedure was followed by the radical prostatectomy and regional lymph node dissection. All cases with extracapsular extension and/or positive margins were scheduled for postoperative radiotherapy. Patients with pT3 to pT4 or node-positive disease received adjuvant hormonal therapy. The application of IORT during radical prostatectomy is feasible and allows the external beam radiotherapy to the tumor bed, without significant acute rectal toxicity. The irradiation with a single dose is convenient when treating in prostate cancer. The survival rate at 41 months has been demonstrated to be of 77%.